Chronic inflammation in diabetic patients may promote carcinogenesis through multifaceted processes such as activation of signal transducer and activator of transcription 3 (STAT-3) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kβ) transcription factors following the production of tumor growth factors or induction of angiogenesis. This evidence concerns the gene NFKB1 and neoplasm.