IFNG and infection: Systemically, anti-chlamydial IFNγ-producing T-cells generally peak 1–2 months after active infection in most antibiotic-treated women (Vicetti et al., 2012); however, in highly-exposed women, IFNγ-producing T-cells that recognize epitopes from C. trachomatis HSP60 correlate with protection against incident C. trachomatis (Cohen et al., 2005).