Recent studies have shown decreased levels of H3K36me3 and H3K79me3 at the upstream and downstream GAA repeat regions of the FXN gene in FRDA cells, indicating that there is a defect in transcription elongation (Punga and Buhler, 2010; Kim et al., 2011; Kumari et al., 2011). The gene discussed is FXN; the disease is Friedreich ataxia.