There is also evidence linking NLRP1 to longevity (Flachsbart et al., 2010), Alzheimer disease (Pontillo et al., 2012), and CVD (Garg, 2011), suggesting it interacts with other lipid related-genes (Sanz et al., 2004; Im et al., 2011). The gene discussed is NLRP1; the disease is early-onset autosomal dominant Alzheimer disease.