NLRP1 and primary adrenal insufficiency: Some of the selective advantage NLRP1 variants have shown association with various autoimmune diseases, including Addison's disease, type I diabetes, and vitiligo, which may suggest that variants in the intergenic region and within NLRP1 may cause differences in susceptibility to infections (Hlaing et al., 2001; Vasseur et al., 2012) and immunity-related disorders (Jin et al., 2007).