Regarding autoimmunity, A20 has been reported as a disease susceptibility gene for human inflammatory and autoimmune pathology, including rheumatoid arthritis (RA) and juvenile idiopathic arthritis, SLE, inflammatory bowel disease (IBD), celiac disease, psoriasis, type 1 diabetes, Sjogren’s syndrome, coronary artery disease, rheumatic heart disease, and systemic sclerosis (163). Here, TNFAIP3 is linked to systemic lupus erythematosus.