Specifically among Flavivirus, infection with DENV showed a time dependent activation of the UPR pathways, with PERK activation and eIF2α phosphorylation during early stages of replication that rapidly switched off, with IRE1 and ATF6 upregulation occurring at mid and late stages in the replication cycle, respectively (Pena and Harris, 2011). This evidence concerns the gene ERN1 and infection.