Along the same line, tumor-inducing viruses encode proteins that target p53, and perhaps there is no tumor in which the p53 pathway itself plus all ascending/descending pathways are fully intact (Gatza et al., 2007; Vousden and Lane, 2007; Feng et al., 2008; Hu et al., 2008; Roemer, 2012). Here, TP53 is linked to neoplasm.