TGFA and pulmonary fibrosis: In addition an important role for αvβ6 in the development of lung fibrosis has been demonstrated using β6 null mice and an anti- αvβ6 integrin antibody in the radiation-induced lung fibrosis mouse model and the TGFα induced lung fibrosis model (Puthawala et al., 2008; Madala et al., 2014).