BECN1 and Alzheimer disease: Interestingly, Beclin-1 was recently considered to be required for efficient phagocytosis and to be reduced in microglia isolated from AD brains (Lucin et al., 2013), thus accounting to explain the reduced phagocytic ability in our 16 DIV cells and to such impairment in mice with AD-like pathology (Krabbe et al., 2013).