This has important implications as the pS935 dephosphorylation is not only observed after LRRK2 kinase inhibition (Deng et al., 2011; Choi et al., 2012; Reith et al., 2012; Zhang et al., 2012), but also in at least some LRRK2 disease mutants (Nichols et al., 2010; Li et al., 2011; Lobbestael et al., 2012; Rudenko et al., 2012), therefore it is not yet clear whether dephosphorylation is a desired effect of a potential PD therapeutic based on LRRK2 kinase inhibition. The gene discussed is LRRK2; the disease is Parkinson disease.