• In all three tumor types with positive steroid receptors the ER+PgR− phenotype showed slower tissue progression rates than the functional ER+PgR+ phenotype (by 38% for Luminal A, 46% for Luminal B1 and 67% for Luminal B2 with Ki67 > 14%), suggesting that if estrogen binding to dysfunctional ERs did not promote PgR expression, it also did not stimulate tissue invasion. This evidence concerns the gene PGR and neoplasm.