In three tumor types with positive steroid receptors the ER+PgR− phenotype showed slower IDC transition than the ER+PgR+ phenotype of the same tumor type (difference in progression rate was 38% for Luminal A, 46% for Luminal B1 and 67% for Luminal B2 with Ki67 > 14%). Here, MKI67 is linked to neoplasm.