APP and Alzheimer disease: For example, genetic variations of SorLa[51] or sorCS1[52], encoding for receptors that are cargoes for the retromer-dependent pathway, are associated with Alzheimer’s disease, expression of VPS35, VPS26, sortilin and SorLa is altered in Alzheimer’s disease patients [53,54] and interfering with expression of VPS26 or VPS35 [55] causes accumulation of amyloid β and APP derivatives in exosomal compartments [56].