To answer this question, we employed two other transgenic mutant LRRK2 lines: the LRRK2(Y1699C) line carrying a confirmed PD pathogenic mutation in the COR domain of LRRK2[26-28], and the LRRK2(I1122V) line with a putative pathogenic mutation in the LRR domain [26,27]. This evidence concerns the gene LRRK2 and Parkinson disease.