LRRK2 and retinal degeneration: Our data presented here independently validate these findings, and extend the relevance of these findings to two other pathogenic LRRK2 mutants, LRRK2(I2020T) and LRRK2(Y1699C), and one putative pathogenic mutant LRRK2(I1122V). More importantly however, we for the first time characterize the functional role of this interaction in regulation of the locomotor activity, lifespan, sensitivity to rotenone and in retinal degeneration.