Based on evidence of the biological function of other 3’UTR variants in cancer, and the association of the BRCA1-3’UTR-variant with breast cancer risk in two previous studies [16,17], we sought to investigate the impact of this variant on BRCA1 expression and its association with tumor biology as seen in clinical presentation in a clinically well-annotated breast cancer population. The gene discussed is BRCA1; the disease is neoplasm.