BRCA1 and metastatic neoplasm: Put differently, 17 (73%) of the 23 patients with metastatic disease at presentation were positive for the BRCA1-3’UTR-variant, compared to 349 (51%) of 680 patients without metastatic lesions (p = 0.040, OR 2.7, 95% CI 1.1-6.9) (Table 2).