SQSTM1 and amyotrophic lateral sclerosis: Following the candidate gene approach identification of SQSTM1 mutation, it has been further reported in ALS and in FTLD (Chen et al., 2014, Hirano et al., 2013, Le Ber et al., 2013, Rubino et al., 2012, Shimizu et al., 2013, Teyssou et al., 2013).