In addition, a comparison of the KEGG “Influenza” pathway (which summarizes the main modules of the type I IFN response pathway) in the stimulated moDCs highlighted three nodes that were down-modulated by C. burnetii and B. abortus (Figure 4), corresponding to the genes encoding TLR3/TLR4, the transcription factor Stat1 and such antiviral response genes as MX1, MX2, OAS1, IFI44 and ADAR. The gene discussed is TLR4; the disease is influenza.