TYMP and hepatocellular carcinoma: Ezaki et al. [27] claimed that “the measurement of thymidine phosphorylase (TP) activity in normal liver tissue adjacent to hepatocellular carcinoma (HCC) may predict multicentric recurrence a long time after an operation.” Ko et al. [28] also stated, “thymidine phosphorylase (TP) is the rate-limiting enzyme for the activation of capecitabine (pro-drug of fluorouracil) and a useful predictor of tumor response to capecitabine-based chemotherapy.” Clearly, the gene “TYMP” represents a hidden connection between the disease and the drug.