In adult acute myeloid leukemia (AML) DNMT3A mutations are found in 14–34% of cases from different series [1], 5–15% of MDS cases [2], 10% of chronic myelomonocytic leukemia (CMML) patients [3], 5.7% of primary myelofibrosis (PMF) patients [4], 12% of cases with systemic mastocytosis [5] and about 18% of T cell acute lymphoblastic leukemia (T-ALL) cases [6]. Here, DNMT3A is linked to acute myeloid leukemia.