Although the stimulated let-7a expression by the ectopic HMGA2 overexpression was not entirely proofed within this study the newly generated CT1258-EGFP-HMGA2 cell line is nevertheless a suitable tool to further investigate the impact of HMGA2 expression on other HMGA2 regulating and regulated genes in canine prostate cancer. The gene discussed is HMGA2; the disease is prostate cancer.