However, immunoblotting analysis of receptor proteins showed that in the center and immediate surrounding area of an ischemic cortical injury, NMDAR1 subunit was strongly reduced during the subacute phase of ischemia, i.e. the first 2 weeks postlesion, the lowest levels in NR1 coinciding in time with the largest functionally silent region, i.e. during the first week [78]. This evidence concerns the gene GRIN1 and ischemia.