The objectives of the study was to (i) compare the effects of IL28B polymorphisms in the progression of HCV infection at two different alleles at rs12979860 and rs8099917 with the prevalent genotype 3 strain circulating in India and (ii) to correlate the effects of the polymorphisms with interferon (IFN) response in different stages of liver diseases with other baseline predictors of response such as age, gender, basal viral load etc in HCV genotype 3 infected individuals. This evidence concerns the gene IFNL3 and liver disorder.