It is also noteworthy that the 37 top deregulated genes were enriched for the myeloma “stem cell” gene set [23], including NUDT11, PKP2, ROBO1, AGAP1, NAP1L3 and EPDR1, indicating that “stemness” may play an important role in determining high risk behavior. The gene discussed is NAP1L3; the disease is plasma cell myeloma.