It is also noteworthy that the 37 top deregulated genes were enriched for the myeloma “stem cell” gene set [23], including NUDT11, PKP2, ROBO1, AGAP1, NAP1L3 and EPDR1, indicating that “stemness” may play an important role in determining high risk behavior. This evidence concerns the gene NUDT11 and plasma cell myeloma.