For example, detection of PAD in such a high risk population may allow for the institution of relatively simple and low cost medical therapies with the potential to improve overall cardiovascular risk such as aspirin, 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors (statins like artovastatin), and angiotensin converting enzyme (ACE) inhibitors [18]. This evidence concerns the gene ACE and peripheral arterial disease.