BCR and chronic myelogenous leukemia, BCR-ABL1 positive: To test a possible link between LASP1 and the BCR-ABL tyrosine kinase that is the predominant driver mutation in CML cells, we subjected BCR-ABL positive (K562, BV173, M07p210) and BCR-ABL negative cell lines for LASP1 expression and pLASP1-Y171 phosphorylation, the known phosphorylation site for ABL kinase [8].