Therefore we propose that under physiological conditions LASP1-CRKL binding is regulated by SRC kinase-mediated phosphorylation of LASP1 while in CML constitutive phosphorylation of CRKL and LASP1 by BCR-ABL abrogates the interaction between these proteins, which may impair cell adhesion and migration. Here, CRKL is linked to chronic myelogenous leukemia, BCR-ABL1 positive.