As seen in Figure 5B, phosphorylation of LASP1 at Ser-146 is not inducing any translocation of the protein to the nucleus and besides, the CML cell lines do not express the LASP1 binding shuttle partner ZO2 as do breast cancer cells (Figure 5C). The gene discussed is TJP2; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.