In brief summary, this is the first evidence that GnT-V suppresses TGF-β1-induced EMT, cell migration and invasion through its catalytic activity in the human lung cancer, which further suggests that GnT-V and its products β1,6-GlcNAc branched N-glycans appear to be responsible for modulating EMT and cancer invasion in lung cancer. Here, MGAT5 is linked to lung carcinoma.