Our own group found overexpression of Abi1 in KRAS-mutated colonic precursor lesions and during colon carcinogenesis [22]; therefore, the aim of this study was to evaluate the expression and functional role of Abi1 in colorectal cancer (CRC) invasion as a prerequisite to tumour cell invasion and metastasis. The gene discussed is KRAS; the disease is colorectal carcinoma.