Accordingly, HDC9 KRAS/BRAF wild-type colorectal carcinoma cells - that weakly express Abi1 [22] - display high levels of E-cadherin and no cleavage of Laminin5 indicated by a single y2′ band migrating at 100–105 kD (Additional file 1: Figure S1A). The gene discussed is ABI1; the disease is colorectal carcinoma.