The expressions of beneficial molecules, such as MnSOD, Trx1 and Bcl-xL (0.71 ± 0.02-fold, 0.61 ± 0.05-fold, and 0.53 ± 0.08-fold vs. donor, respectively) are all decreased in advanced heart failure (Figure 2A and B). The gene discussed is SOD2; the disease is advanced heart failure.