A mechanistic approach is relevant, given that LKB1 acts either as an inducer or suppressor of apoptosis in a cell-type dependent manner that is linked with the severity of energy stress[23-25], and activation of the LKB1-AMPK pathway decreases ATP-consuming processes while increasing ATP production, which fits well with the energy-compromised status of aggressive cancer cells. The gene discussed is STK11; the disease is cancer.