Previously, we have demonstrated the cardio-protection of green tea polyphenols (GTPs) against oxidative stress associated with myocardial ischemic injury by reducing cytosolic Ca2+ overload and generation of ROS via the Akt/GSK-3β/β-catenine and caveolae signaling in a rat surgical model of myocardial ischemia and in an H2O2-induced oxidative stress model of H9c2 rat cardiomyoblasts [11,24-26]. The gene discussed is GSK3B; the disease is myocardial ischemia.