NQO1 and colon adenocarcinoma: In addition, studies of Yao et al. showed that induction of the NQO1 gene by hypoxia and mitomycin C in human colon adenocarcinoma HT29 and human hepatoma HepG2 cells was mediated through a mechanism involving the NF-κB signaling pathway [34,35], which has been shown to play an important role in proliferation, resistance to apoptosis, invasion, and metastasis of HeLa cells [36,37].