To further illustrate that NQO1 was a potential effective predictor of poor prognosis, we analyzed the correlation between NQO1 expression and clinicopathological features of cervical SCCs, and found that high-level expression of the NQO1 protein was significantly correlated with poor differentiation, late clinical stage, and the presence of lymph node metastasis (P < 0.05). This evidence concerns the gene NQO1 and metastatic malignant neoplasm in the lymph nodes.