The role of FBW7 regulating two known tumor suppressors, both of which are RasGAPs, for degradation, suggest a potential unifying role of DAB2IP and NF1 being under the control of Fbw7-mediated degradation which requires further studies of these pathways and their stability control by Fbw7 to elucidate the implications in cancer development and progression. This evidence concerns the gene DAB2IP and cancer.