The role of FBW7 regulating two known tumor suppressors, both of which are RasGAPs, for degradation, suggest a potential unifying role of DAB2IP and NF1 being under the control of Fbw7-mediated degradation which requires further studies of these pathways and their stability control by Fbw7 to elucidate the implications in cancer development and progression. Here, FBXW7 is linked to cancer.