These include mainly the early innate immune response genes responsible for cytokine-cytokine receptor interactions (CXCL16, CCR1, CCR3, CNTF, CSF2RA, IFNGR1, TNFSF9, TNFSF12, TNFSF13, TNFSF13B, TNFRSF1A, TNFRSF1B, IL1A, IL15, IL18, IL1RAP, IL1R2, IL18RAP), genes involved in toll-like receptor pathway (TLR4, TLR2, MYD88, CD14, LY96), NF-Kappa B signalling pathway (NFKBIA, TNFRSF1A, TNFSF13B), NOD-like receptor signalling pathway (CASP1, PSTPIP1, IL18, NFKBIA) or otherwise linked to response to bacterial infections (SLC11A1, SERPINB1, S100A8, S100A9, S100A12, ARG2, CEBPB). This evidence concerns the gene IL1RAP and bacterial infectious disease.