TLR4 and bacterial infectious disease: These include mainly the early innate immune response genes responsible for cytokine-cytokine receptor interactions (CXCL16, CCR1, CCR3, CNTF, CSF2RA, IFNGR1, TNFSF9, TNFSF12, TNFSF13, TNFSF13B, TNFRSF1A, TNFRSF1B, IL1A, IL15, IL18, IL1RAP, IL1R2, IL18RAP), genes involved in toll-like receptor pathway (TLR4, TLR2, MYD88, CD14, LY96), NF-Kappa B signalling pathway (NFKBIA, TNFRSF1A, TNFSF13B), NOD-like receptor signalling pathway (CASP1, PSTPIP1, IL18, NFKBIA) or otherwise linked to response to bacterial infections (SLC11A1, SERPINB1, S100A8, S100A9, S100A12, ARG2, CEBPB).