DBNL and lung cancer: The demonstrated importance of the S269/T291-phosphosensor sites of HIP-55 in mediating 14-3-3 binding and acquired tumorigenic properties of lung cancer cells supports HIP-55 as a novel oncogenic signaling hub that integrates multiple growth regulatory cues through defined functional domains, actin-binding, phospho-sensing, and SH3 modules[23,36-40].