The expression of HIP-55 protein was probed in a panel of lung cancer cell lines including those from adenocarcinomas (AC), large cell carcinomas (LCC), and squamous cell cancers (SCC), as well as the cultured human normal bronchial epithelial cell line, BEAS-2B. The gene discussed is DBNL; the disease is leukoencephalopathy with calcifications and cysts.