In contrast to WT HIP-55, the HIP-55/AA mutant exhibited reduced promotion of tumor growth in SCID mice which is consistent with results from the in vitro colony formation assay as shown in Figure 2G, demonstrating that HIP-55 promotes tumor growth in vivo likely through a HIP-55/14-3-3 complex-dependent mechanism. The gene discussed is DBNL; the disease is neoplasm.