A recent ALL-research article (Braoudaki et al., 2013) using 2DE-gels coupled to MALDI, shows that proteins such as CLUS, CERU, APOE, APOA4, APOA1, GELS, S10A9, AMBP, ACTB, CATA and AFAM are playing an important function in leukaemia prognosis, possibly acting as distinctive biomarkers for leukaemia aggressiveness, or as suppressor proteins in HR (high risk)-ALL paediatric cases [49]. Here, APOE is linked to leukemia.