Drugs which improve CVD mortality such as statins, β-blockers, ACE-inhibitors, and angiotensin receptor blockers have all shown beneficial effects on endothelial function as measured by forearm responses to ACh [31], [49]–[51], but no study has demonstrated that the reversal of endothelial dysfunction with an active intervention also alters CVD mortality in the same individuals. The gene discussed is ACE; the disease is endothelial dysfunction.