CDKN2A and malignant colon neoplasm: In cancer progression, Kang et al. report an association of p14ARF (CDKN2A) polymorphisms with the likelihood of methylation of this gene within colorectal cancers [34], while Boumber et al. report an indel polymorphism in the PDLIM4 that influences its methylation in leukemia and colon cancer [35].