Recently different studies demonstrating the presence of IL-5, IL-17 and IFNγ, eosinophilic cationic protein (ECP), myeloperoxidase (MPO) and local IgE in homogenatesfrom CRSwNP tissue support the presence of different T cell subsets and consecutive variations in the inflammatory patterns [9], [10]. Here, RNASE3 is linked to chronic rhinosinusitis with nasal polyps.