Levels of IL-1β, IL-6, IL-8, IL-17, and IFNγ showed no significant difference between control, CRSsNP and CSRwNP groups, while in CF-NP, a significant increase of IL-1β and IL-17 vs. control and CRSwNP was observed. This evidence concerns the gene CXCL8 and chronic rhinosinusitis without nasal polyps.