A tendency towards a positive association of *04:05 and *14:54 with ACPA(−) RA was observed (*04:05: P = 0.0126, Pc = 0.3667, OR 1.75, 95% CI 1.15–2.69;*14:54: P = 0.0202, OR 2.25, Pc = 0.5861, 95% CI 1.17–4.32). Here, PRTN3 is linked to rheumatoid arthritis.