The persistent depolarization is pro-apoptotic, because some cardiac glycoside inhibitors of Na+–K+-ATPase such as ouabain and oleandrin, can sensitize human leukemia cells and NSCLC cells to apoptosis induced by anti-Fas, TRAIL, and mitochondrial toxins (14, 15, 18). Here, TNFSF10 is linked to non-small cell lung carcinoma.