Interestingly, it is reported that in B-chronic lymphocytic leukemia (B-CLL), miR-15a/ 16–1 are hosted by DLEU2, a regulatory gene which is frequently deleted in CLL leading to repression of miR-15-a/16 (thus cell cycle progression, proliferation and anti-apoptosis) [30]. Here, DLEU2 is linked to B-cell chronic lymphocytic leukemia.