miRNAs (miRs) have become an interesting research focus in MM as these molecules are mostly deregulated in MM, can have multiple targets (which may be oncogenes or tumor suppressor genes, e.g. MYC, TP53, PTEN) and have proved to significantly influence MM tumor in vitro and in vivo[7-12]. The gene discussed is TP53; the disease is Miyoshi myopathy.