In the subgroup of OAS patients we found a significantly elevated IgE reactivity to some pollen and pollen related components like rCor a 1.0101 (p = 0.022), rPru p 1, rAra h 8 (p = 0.036) in samples taken during the pollen season, and to rCor a 1.0101 (p = 0.013), to rPru p 1(p = 0.037) as well as r Ara h 8 (p = 0.020) in samples taken off-season. Here, IGHE is linked to microphthalmia with limb anomalies.