Several studies have introduced animal models of PCOS to assess the effects of prenatal exposure of animals to androgen excess; for example in mice, rats, sheep and monkeys, prenatal androgenized animals showed many symptoms of PCOS after puberty such as hyperandrogenemia, increased LH secretion, polycystic ovary, oligoovulation and some others (2, 5, 10, 11). Here, PLOD1 is linked to polycystic ovary syndrome.