And fourth, germline mutations in nuclear deubiquitinase BRCA1-associated protein 1 (BAP1) have been observed in familial clusters of mesothelioma not necessarily linked to asbestos (Testa et al., 2011) and in a fraction of pleural mesotheliomas in other case series (Bott et al., 2011; Jean et al., 2012; Tallet et al., 2013). The gene discussed is BAP1; the disease is mesothelioma.