SSX2 and synovial sarcoma: Indeed, Sandberg (2002) provides a summary of specific chromosomal translocations corresponding to a variety of soft tissue sarcomas including synovial sarcoma where—the translocation is the sole cytogenetic anomaly, indicating the probable causative role of this translocation in the genesis of these tumors. In synovial sarcoma, the normal SYT gene encodes a transcription factor whereas the SSX1 and SSX2 genes produce proteins that are transcription inhibitors.