Furthermore, in a mouse model of Huntington's disease characterized by striatal degeneration and deterioration in motor behavior, the impaired production of BDNF contributes to striatal degeneration and progressive motor abnormalities (Saudou and Humbert, 2008; Zuccato et al., 2010; Samadi et al., 2013). This evidence concerns the gene BDNF and juvenile Huntington disease.