HSPG2 and myocardial ischemia: P2 receptors have been also proposed as potential therapeutic targets in the cardiac ischemia setting; in particular, the P2X-type receptors with their pleiotropic functions on cardiac cells ion permeability, or the P2Y-type receptors, which are coupled to Gq, Gs or Gi proteins and elicit activator or inhibitory actions on PLC or adenylate cyclase in a variety of cardiac cells [35].