In developed countries, prostate cancer (PCa) is the most common noncutaneous cancer in males, but with the widespread use of prostate-specific antigen (PSA) testing and prostate biopsies, the majority of prostate tumors now diagnosed are localized (i.e., confined within the prostate gland), slow growing, and unlikely to metastasise 1. Here, KLK3 is linked to posterior cortical atrophy.