Although no mouse model can fully recapitulate the development and features of psoriasis (Gudjonsson et al., 2007), topical application of the imiquimod (IMQ)-containing cream Aldara induces a psoriasiform skin inflammation, which exhibits most of the crucial traits (Swindell et al., 2011) including acanthosis, parakeratosis, neutrophil recruitment, and involvement of the IL-23-IL-17-IL-22 pathway (van der Fits et al., 2009), and is thus increasingly used to dissect the mechanisms of psoriasis pathogenesis. This evidence concerns the gene IL17A and psoriasis.