In fact, (R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide dihydrochloride (Y-27632) [18] is a specific ROCK inhibitor that suppresses tumor growth and metastasis, indicating that the Rho/ROCK pathway may be a good target for preventing tumor invasion and metastasis [19,20]. Here, RHO is linked to neoplasm.