We performed this meta-analysis, to compare the difference in EGFR TKI efficacy and determine the prognosis of advanced NSCLC patients with the two common subtypes of EGFR mutations (exon 19del and exon L858R), aiming to more accurately predict the response to EGFR TKIs and the prognosis for advanced NSCLC patients with activating EGFR mutations. This evidence concerns the gene EGFR and non-small cell lung carcinoma.