In our drug targets list related to autophagy mediators (Figure 6), other molecular targets could be considered suitable for therapeutic intervention including AMPK-related proteins, a highly ranked protein in our network (Table 3 and Additional file3: Table S3) and a target which has been already considered for the treatment of Alzheimer’s disease. The gene discussed is PRKAA2; the disease is early-onset autosomal dominant Alzheimer disease.