Analyzing in more detail these autophagy mediators and the molecular link to the specific disease genes, AD and FTD-related mediator proteins appears to be mainly associated to the initiation complex of the macroautophagy cascade, involving mainly beclin 1 interactome: B-cell CLL/lymphoma 2 (BCL2), BCL2-like 1 (BCL2L1), and Atg14 (Figure 6). Here, BCL2 is linked to Alzheimer disease.