Furthermore, two de novo damaging missense mutations [c.A1436G/p.Y460C; c.C3640G/p.P1195A] in the very long linker region between zinc fingers 3 and 4, and between 11 and 12, respectively, of the ZNF407 gene were found in one intellectual impairment patient each. This evidence concerns the gene ZNF407 and Cognitive impairment.